Renutrin® is backed by clear and detailed research.
Supported by 15 clinical studies in healthy adults, and adults with prediabetes and type 2 diabetes
Supported by 15 clinical studies in healthy adults, and adults with prediabetes and type 2 diabetes
Mulberry Leaf Extract
200 mg of mulberry leaf extract (the amount in each serving of Renutrin®) lowers post-meal blood sugar by ~20-30% after meals by blocking the enzyme that breaks down starch.

Research on mulberry leaf extract (MLE)
Cui et al. Food & Function 2023. This systematic review and meta-analysis found long-term (≥8 weeks) intake of MLE reduced fasting blood glucose by -8.5 mg/dL, A1c by -2.4% and fasting insulin by -4 pmol/L and was most effective in adults with prediabetes.
Thondre et al. Nutrients 2024. 200 mg of MLE - the same amount in one dose of Renutrin decreased glucose by -30% and insulin by 31% in healthy adults.
Ding et al. Plos One 2023. MLB added to bread significantly reduced glucose in health adults.
Mohamed et al. Diab Ther 2023. MLE reduced glucose by -20% and insulin by -24% in adults with type 2 diabetes.
Takahashi et al. Eur J Clin Nutr 2023. MLE significantly lowered glucose in healthy adults.
Ghelof et al. Nutrients 2022. MLE reduced glucose by- 26% in healthy adults.
Thondre et al. Nutr & Metab 2021. 250 mg MLE reduced glucose by -42%, insulin by -40%, peak glucose by -40%, and peak insulin by -41% in healthy adults.
Wang et al. Medicine. 2018. MLE reduced glucose up to 53% in healthy adults.
Lown et al. Plos One 2017. 250 mg MLE lowered glucose by -14% and insulin by 24% in healthy adults.

The Formula
Renutrin® has just 2 Ingredients: Mulberry Leaf Extract and Resistant Potato Starch
Renutrin® has just 2 Ingredients: Mulberry Leaf Extract and Resistant Potato Starch
Resistant Potato Starch
3.5 g of resistant potato starch (Renutrin® has 4.5 g/serving) has a prebiotic effect.
Gut microbes break down resistant starch to produce short chain fatty acids. These acids bind to the cells that line our intestine and causes other metabolites to be released (one is GLP-1) that regulate blood sugar and insulin, inflammation, metabolism, appetite, and many other host benefits.

Research on resistant potato starch (RPS)
Bush et al. BMC Nutr 2024. RPS did not change abdominal pain, gas, or discomfort levels from baseline showing good tolerance.
Bush et al. Metabolites 2024. RPS improved free fatty acid levels and conjugated bile acids that are linked to metabolic health.
Bush et al. Nutrients 2023. RPS increases Bifidobacterium and Akkermansia gut bacteria as well as improved regularity.
Bush et al. J Fun Foods 2023. RPS reduced gut histamine and markers linked to leaky gut.
Cao et al. Nutrients 2022. RPS reduced intestinal inflammation markers in adults with metabolic syndrome.
Sanders et al. J Hum Nutr Diet 2020. RPS reduced fasting glucose and free fatty acids, both associated with metabolic health.
Patterson et al. Nutrients 2019. RPS reduced peak glucose by -9.2% and peak insulin by -23% in overweight females.
Maiya et al. Nutr Res 2023. This narrative review found that resistant starch intake over 8 weeks improved cardiometabolic outcomes in adults with type 2 diabetes.
Dr. Mindy's Publications
Zoellner E, Patterson M, Sharrief A, Savitz S, Tucker W. Dietary intake and quality among stroke survivors in the National Health and Nutrition Examination Survey: 1999 -2018 J Nutr (2023)
Combest S, Warren C, Grams M, Miketinas D, Patterson M. Evaluation of Brewers' Spent Grain on Cardiovascular Disease Risk Factors in Adults: Lessons Learned from a Pilot Study
Bio Carb Diet Fibre (2023)
Maiya M, Adorno A, Toulabi S, Tucker WJ, Patterson MA. Resistant starch and cardiometabolic outcomes: A narrative review of randomized trials
Nutr Res (2023)
Miketinas DC, Tucker WJ, Douglas CC, Patterson MA. Usual dietary fiber intake according to diabetes status in US adults: NHANES 2013-2018 Brit J Nutr (2023)
Fong JVN, Miketinas DC, Moore L, Ajami N, Patterson MA. Precision nutrition model predicts glucose control of overweight females following the consumption of potatoes high in resistant starch Nutrients (2022)
Silva FB, Osborn DE, Owens MR, Kirkland T, Moore CE, Patterson MA, Tucker WJ, Miketinas DC, Davis KE. Influence of COVID-19 pandemic restrictions on college students' dietary quality and experience of the food environment
Nutrients (2021)
Owens MR, BritoSilva F, Kirkland T, Moore CE, Davis KE, Patterson MA, Miketinas DC, Tucker WJ. Prevalence and social determinants of food insecurity among college students during the COVID-19 pandemic Nutrients (2020)
Miketinas DC, Shankar K, Maiya M, Patterson MA. Usual dietary intake of resistant starch in United States adults from NHANES 2015-2016
J Nutr (2020)
Patterson MA, Maiya M, Stewart ML. Resistant starch in foods commonly consumed in the United States: A narrative review
J Acad Nutr Diet (2020)
Patterson MA, Fong JN, Maiya M, Kung S, Sarkissian A, Nashef N, Wang W. Chilled potatoes decrease postprandial glucose, insulin, and glucose-dependent insulinotropic peptide compared to boiled potatoes in females with elevated fasting glucose and insulin. Nutrients (2019)
Bertagnolli EJ, Patterson MA, Utech A, Walker RN. Accuracy of water delivery in enteral nutrition pumps
Nutr Clin Pract (2019)
Burch H, Moore C, Burditt J, Patterson M. Measuring the nutrition knowledge of weight management and diabetes risk in a low socioeconomic population
Top Clin Nutr (2019)
Patterson M, Wang W, Ortiz A. Dietary and physical activity outcomes determine energy balance in U.S. adults aged 50-74
J Aging Phys Act (2018)
Patterson M, Preisendanz S, Juma S, Imrhan V, Prasad C. Resistant starch lowers postprandial glucose and leptin in overweight adults consuming a moderate-to-high fat diet: a randomized-controlled trial Nutr J (2017)
Prasad C, Imrhan V, Juma S, Patterson M, Prasad A. Bioactive plant metabolites in the management of non-communicable metabolic diseases: Looking at opportunities beyond the horizon
Metabolites (2015)
Chapters
Macronutrients
in Clinical Nutrition in Athletic Training | Slack, Inc (2022)
Mindy A. Patterson
Health and Wellness Programs in Older Adults in Handbook of Rehabilitation in Older Adults | Springer (2019)
Wayne Brewer, Mindy Patterson, Christopher Ray